July 2020 - March 2021 Member Publications

1. Oshunbade AA, Kassahun-Yimer W, Valle KA, Hamid A, Kipchumba RK, Kamimura D, Clark D 3rd, White WB, DeFilippis AP, Blaha MJ, Benjamin EJ, O'Brien EC, Mentz RJ, Rodriguez CJ, Fox ER, Butler J, Keith RJ, Bhatnagar A, Marie Robertson R, Correa A, Hall ME. Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2021 Apr 6;10(7):e017320. doi: 10.1161/JAHA.120.017320. Epub 2021 Mar 23. PMID: 33754833.
   Impact Statement: In Black individuals cigarette smoking can exacerbate heart failure and increase the risk of hospital admissions for heart failure

    

2. Keith R, Bhatnagar A. Cardiorespiratory and Immunologic Effects of Electronic Cigarettes. Curr Addict Rep. 2021 Mar 5:1-11. doi: 10.1007/s40429-021-00359-7. Epub ahead of print. PMID: 33717828; PMCID: PMC7935224. 
   Impact Statement: This review discusses evidence showing that the use of e-cigarettes is associated with a range of cardiovascular and immunological changes that could be detrimental to health

    

3. Ohanyan V, Raph SM, Dwenger MM, Hu X, Pucci T, Mack G, Moore JB 4th, Chilian WM, Bhatnagar A, Nystoriak MA. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins. Circ Res. 2021 Mar 19;128(6):738-751. doi: 10.1161/CIRCRESAHA.120.317715. Epub 2021 Jan 27. PMID: 33499656.
   Impact Statement: This study shows that the increase in oxygen demand in the heart, due to exercise or exertion, is met by increase blood flow in the heart, which is regulated by potassium channels and their subunits.

    

4. Men H, Cai H, Cheng Q, Zhou W, Wang X, Huang S, Zheng Y, Cai L. The regulatory roles of p53 in cardiovascular health and disease. Cell Mol Life Sci. 2021 Mar;78(5):2001-2018. doi: 10.1007/s00018-020-03694-6. Epub 2020 Nov 11. PMID: 33179140
   Impact Statement: Except for regulating a myriad of genes to maintain normal cell functions, this study found the important roles of p53 in the cardiovascular physiological and pathological conditions as revealed by this review: primarily, p53 determines the fates of cardiomyocytes by regulating metabolism and programmed cell death and also regulates cell cycle arrest and angiogenesis in non-myocytes, thus participating in the regulation of CVDs.

    

5. Wahlang B, Alexander NC 2nd, Li X, Rouchka EC, Kirpich IA, Cave MC. Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. Toxicol Rep. 2021 Mar 10;8:536-547. doi: 10.1016/j.toxrep.2021.03.010. PMID: 33777700; PMCID: PMC7985695 
   Impact Statement: This publication elucidated mechanism by which polychlorinated biphenyls and their nuclear receptor targets, PXR and CAR, modulate the gut:liver axis thereby impacting susceptibility to obesity-related diseases.

    

6. O'Brien SJ, Ellis CT, McDowell J, Galandiuk S, Polk HC Jr. Anal squamous cell carcinoma incidentally found at hemorrhoidectomy. Surgery. 2021 Mar;169(3):610-616. doi: 10.1016/j.surg.2020.08.026. Epub 2020 Sep 29. PMID: 33004218.
   Impact Statement: Anal cancer (SSCA) is on the rise and Kentucky now has the second highest incidence rate. Although this cancer is strongly associated with Human Papilloma Virus (HPV), it doesn’t completely explain its temporal trend. Three percent of all SCCA cases in KY were found at the time of hemorrhoidectomy.

    

7. Hill BG, Rood B, Ribble A, Haberzettl P. Fine particulate matter (PM2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance. Am J Physiol Heart Circ Physiol. 2021 Mar 5. doi: 10.1152/ajpheart.00881.2020. Epub ahead of print. PMID: 33666505
   Impact Statement: We found that inhalation of fine particulate matter air pollution induces vascular inflammation and insulin resistance via circulating plasma constituents possibly by promoting a unique form of dyslipidemia that dependents on pulmonary oxidative stress.

    

8. Kumar A, Ren Y, Sundaram K, Mu J, Sriwastva MK, Dryden GW, Lei C, Zhang L, Yan J, Zhang X, Park JW, Merchant ML, Teng Y, Zhang HG. miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene. Theranostics. 2021 Feb 19;11(9):4061-4077. doi: 10.7150/thno.52558. PMID: 33754048; PMCID: PMC7977461.
   Impact Statement: The molecular mechanisms that mediate diet-based prevention of insulin resistance are not well understood. In this proof-of-concept study, ginger-derived nanoparticles (GDNP) were used to examine a role for GDNP-supplemented diet in amelioration of high-fat diet (HFD) induced insulin resistance. Using multiple lines of inquiry, this study revealed that oral administration of GDNP to HFD mice improved host glucose tolerance and insulin response via (1) regulating VAMP7 induction, (2) enhanced the exosomal accumulation of microRNA miR-375 culminating in (3) the inhibition of arylhydrocarbon receptor (AhR) expression and signaling

    

9. Hardesty JE, Wahlang B, Prough RA, Head KZ, Wilkey D, Merchant M, Shi H, Jin J, Cave MC. Effect of Epidermal Growth Factor Treatment and Polychlorinated Biphenyl Exposure in a Dietary-Exposure Mouse Model of Steatohepatitis. Environ Health Perspect. 2021 Mar;129(3):37010. doi: 10.1289/EHP8222. Epub 2021 Mar 31. PMID: 33788613; PMCID: PMC8011667
   Impact Statement: Our initial research demonstrated that some PCBs bind to the Epidermal Growth Factor Receptor (EGFR) and terminate its activation of normal gene expression in liver. We sought to establish whether co-treatment with epidermal growth factor, a ligand activator for EGFR, would reverse this inhibition by PCBs. While EGR did reverse the action of PCBs as proposed, there were other downstream effects caused by EGR suggesting the growth factor probably wouldn't serve as a therapeutic agent to prevent PCB toxicity due to its side effects.

    

10. Das S, Rai SN. SwarnSeq: An improved statistical approach for differential expression analysis of single-cell RNA-seq data. Genomics. 2021 Mar 1;113(3):1308-1324. doi: 10.1016/j.ygeno.2021.02.014. Epub ahead of print. PMID:33662531. 
    Impact Statement: This publication discusses the development of an efficient method for analysis of Single-cell RNA sequencing data. This new method is compared with 11 methods on 10 data sets.

     

11. Fuqua JL, Rouchka EC, Waigel S, Sokoloski K, Chung D, Zacharias W, Zhang M, Chariker J, Talley D, Santisteban I, Varsani A, Moyer S, Holm RH, Yeager RA, Smith T, Bhatnagar A. A rapid assessment of wastewater for genomic surveillance of SARS-CoV-2 variants at sewershed scale in Louisville, KY. medRxiv [Preprint]. 2021 Mar 26:2021.03.18.21253604. doi: 10.1101/2021.03.18.21253604. PMID: 33791725; PMCID: PMC8010757.
    Impact Statement: This paper describes preliminary observations and methodological refinements for wastewater-based surveillance of SARS-CoV-2 variants of concern. This work will inform future wastewater-based COVID-19 surveillance and targeted response to the spread of variants

     

12. Yuan J, Zhang Y, Zhang Y, Mo Y, Zhang Q. Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes. Part Fibre Toxicol. 2021 Mar 19;18(1):13. doi: 10.1186/s12989-021-00405-2. PMID: 33740985; PMCID: PMC7980342.
    Impact Statement: The results of this study have demonstrated whether and how exposure to metal nanoparticles causes skin diseases such as skin inflammation and allergy, which also provided tools for evaluating the health effects of other metal nanomaterials. This study not only leads to a better understanding of the mechanisms by which metal nanoparticles induce skin inflammation and allergy, but also provide scientific evidence to prevent and control them.

Congratulations to the CIEHS members with articles published in February! This list also includes publications that were ahead of print during the months of December and January (member names will be bolded):

1. Farley G, Riggs DW, Bhatnagar A, Hellmann J. Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness. Clin Nutr. 2021 Feb 11:S0261-5614(21)00080-7. doi: 10.1016/j.clnu.2021.02.006. Epub ahead of print. PMID: 33618966.

    

2. Wang X, Chen X, Xu H, Zhou S, Zheng Y, Keller BB, Cai L. Emerging roles of microRNA-208a in cardiology and reverse cardio-oncology. Med Res Rev. 2021 Feb 3. doi: 10.1002/med.21790. Epub ahead of print. PMID: 33533026.

    

3. Li Y, Fan H, Yuan F, Lu L, Liu J, Feng W, Zhang HG, Chen SY. Sulforaphane Protects Against Ethanol-Induced Apoptosis in Human Neural Crest Cells Through Diminishing Ethanol-Induced Hypermethylation at the Promoters of the Genes Encoding the Inhibitor of Apoptosis Proteins. Front Cell Dev Biol. 2021 Feb 9;9:622152. doi: 10.3389/fcell.2021.622152. PMID: 33634123; PMCID: PMC7900432.

    

4. Clifford SP, Ramirez J, Akca O, Ghafghazi S, Huang J. Perioperative Cardiac Research Considerations During the Coronavirus Disease 2019 (COVID-19) Pandemic. J Cardiothorac Vasc Anesth. 2021 Feb 5:S1053-0770(21)00089-6. doi: 10.1053/j.jvca.2021.01.052. Epub ahead of print. PMID: 33618962; PMCID: PMC7863767.

    

5. Cardarelli KM, Ickes M, Huntington-Moskos L, Wilmhoff C, Larck A, Pinney SM, Hahn EJ. Authentic Youth Engagement in Environmental Health Research and Advocacy. Int J Environ Res Public Health. 2021 Feb 23;18(4):2154. doi: 10.3390/ijerph18042154. PMID: 33672107; PMCID: PMC7926324.

    

6. Ghosh S, Whitley CS, Haribabu B, Jala VR. Regulation of Intestinal Barrier Function by Microbial Metabolites. Cell Mol Gastroenterol Hepatol. 2021;11(5):1463-1482. doi: 10.1016/j.jcmgh.2021.02.007. Epub 2021 Feb 18. PMID: 33610769; PMCID: PMC8025057.

    

7. Landers VD, Wilkey DW, Merchant ML, Mitchell TC, Sokoloski KJ. The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling. Viruses. 2021 Feb 27;13(3):377. doi: 10.3390/v13030377. PMID: 33673546.

    

8. Caster DJ, Korte EA, Merchant ML, Klein JB, Barati MT, Joglekar A, Wilkey DW, Coventry S, Hata J, Rovin BH, Harley JB, Namjou-Khales B, McLeish KR, Powell DW. Patients with Proliferative Lupus Nephritis Have Autoantibodies That React to Moesin and Demonstrate Increased Glomerular Moesin Expression. J Clin Med. 2021 Feb 16;10(4):793. doi: 10.3390/jcm10040793. PMID: 33669337; PMCID: PMC7920286.

    

9. Singh P, O'Toole TE, Conklin DJ, Hill BG, Haberzettl P. Endothelial Progenitor Cells as Critical Mediators of Environmental Air Pollution-Induced Cardiovascular Toxicity. Am J Physiol Heart Circ Physiol. 2021 Feb 19. doi: 10.1152/ajpheart.00804.2020. Epub ahead of print. PMID: 33606580.

    

10. Kaplin A, Junker C, Kumar A, Ribeiro MA, Yu E, Wang M, Smith T, Rai SN, Bhatnagar A. Evidence and magnitude of the effects of meteorological changes on SARS-CoV-2 transmission. PLoS One. 2021 Feb 17;16(2):e0246167. doi: 10.1371/journal.pone.0246167. PMID: 33596214; PMCID: PMC7888632.

     

11. McGraw KE, Riggs DW, Rai S, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy S, Taylor KC, Conklin DJ, DeFilippis AP, Srivastava S, Bhatnagar A. Exposure to Volatile Organic Compounds - Acrolein, 1,3-Butadiene, and Crotonaldehyde - is Associated with Vascular Dysfunction. Environ Res. 2021 Feb 23:110903. doi: 10.1016/j.envres.2021.110903. Epub ahead of print. PMID: 33636185.

     

12. Jin L, Lynch J, Richardson A, Lorkiewicz P, Srivastava S, Theis W, Shirk G, Hand A, Bhatnagar A, Srivastava S, Conklin DJ. Electronic Cigarette Solvents, Pulmonary Irritation and Endothelial Dysfunction:Role of Acetaldehyde and Formaldehyde. Am J Physiol Heart Circ Physiol. 2021 Feb 5. doi: 10.1152/ajpheart.00878.2020. Epub ahead of print. PMID: 33543686.

     

13. Poirier MC, Marsili L, Fossi MC, Godard-Codding CAJ, Hernandez-Ramon EE, Si N, Divi KV, Divi RL, Kerr I, Wise JP, Wise CF, Wise SS, Aboueissa AM, Wise JTF, Wise JP. Polycyclic Aromatic Hydrocarbon-DNA Adducts in Gulf of Mexico Sperm Whale Skin Biopsies Collected in 2012. Toxicol Sci. 2021 Feb 10:kfab016. doi: 10.1093/toxsci/kfab016. Epub ahead of print. PMID: 33566103

 Publications from the months of December and January: 

1. Haweel R, Shalaby A, Mahmoud A, Seada N, Ghoniemy S, Ghazal M, Casanova MF, Barnes GN, El-Baz A. A Robust DWT-CNN Based CAD System for Early Diagnosis of Autism Using Task-based fMRI. Med Phys. 2020 Dec 30. doi: 10.1002/mp.14692. Epub ahead of print. PMID: 33378589.

    

2. Fontenele RS, Kraberger S, Hadfield J, Driver EM, Bowes D, Holland LA, Faleye TOC, Adhikari S, Kumar R, Inchausti R, Holmes WK, Deitrick S, Brown P, Duty D, Smith T, Bhatnagar A, Yeager RA, Holm RH, Hoogesteijn von Reitzenstein N, Wheeler E, Dixon K, Constantine T, Wilson MA, Lim ES, Jiang X, Halden RU, Scotch M, Varsani A. High-throughput sequencing of SARS-CoV-2 in wastewater provides insights into circulating variants. medRxiv [Preprint]. 2021 Jan 25:2021.01.22.21250320. doi: 10.1101/2021.01.22.21250320. PMID: 33501452; PMCID: PMC7836124.

    

3. Stokes AC, Xie W, Wilson AE, Yang H, Orimoloye OA, Harlow AF, Fetterman JL, DeFilippis AP, Benjamin EJ, Robertson RM, Bhatnagar A, Hamburg NM, Blaha MJ. Association of Cigarette and Electronic Cigarette Use Patterns With Levels of Inflammatory and Oxidative Stress Biomarkers Among US Adults: Population Assessment of Tobacco and Health Study. Circulation. 2021 Jan 4. doi: 10.1161/CIRCULATIONAHA.120.051551. Epub ahead of print. PMID: 33390037.

    

4. Harlow AF, Fetterman JL, Ross CS, Robertson RM, Bhatnagar A, Benjamin EJ, Stokes AC. Association of device type, flavours and vaping behaviour with tobacco product transitions among adult electronic cigarette users in the USA. Tob Control. 2021 Jan 21:tobaccocontrol-2020-055999. doi: 10.1136/tobaccocontrol-2020-055999. Epub ahead of print. PMID: 33479031

    

5. Li J, Liu L, Zhou WQ, Cai L, Xu ZG, Rane MJ. Roles of Krüppel-like factor 5 in kidney disease. J Cell Mol Med. 2021 Feb 1. doi: 10.1111/jcmm.16332. Epub ahead of print. PMID: 33523554.

    

6. Yearwood EL, Hines-Martin VP. Editorial: Impact of social determinants of health on mental health. Arch Psychiatr Nurs. 2021 Feb;35(1):A1-A2. doi: 10.1016/j.apnu.2020.12.001. Epub 2021 Jan 8. PMID: 33593523.

    

7. Wei P, Li J, Huang J, Zhang T, Tang W. Radial artery catheterisation pressure monitoring with a closed intravascular catheter system and ultrasound-guided dynamic needle tip positioning technique. Br J Anaesth. 2021 Jan 26:S0007-0912(20)31055-2. doi: 10.1016/j.bja.2020.12.033. Epub ahead of print. PMID: 33514485.

    

8. Eldeirawi K, Huntington-Moskos L, Nyenhuis SM, Polivka B. Increased disinfectant use among adults with asthma in the era of COVID-19. J Allergy Clin Immunol Pract. 2021 Mar;9(3):1378-1380.e2. doi: 10.1016/j.jaip.2020.12.038. Epub 2020 Dec 29. PMID: 33385592; PMCID: PMC7832809

    

9. Swovick K, Firsanov D, Welle KA, Hryhorenko JR, Wise JP Sr, George C, Sformo TL, Seluanov A, Gorbunova V, Ghaemmaghami S. Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands. Mol Cell Proteomics. 2021 Jan 7;20:100041. doi: 10.1074/mcp.RA120.002301. Epub ahead of print. PMID: 33639418.

    

10. Riggs DW, Yeager R, Conklin DJ, DeJarnett N, Keith RJ, DeFilippis AP, Rai SN, Bhatnagar A. Residential Proximity to Greenness Mitigates the Hemodynamic Effects of Ambient Air Pollution. Am J Physiol Heart Circ Physiol. 2021 Jan 8. doi: 10.1152/ajpheart.00689.2020. Epub ahead of print. PMID: 33416460.

1. Metcalf S, Petri BJ, Kruer T, Green B, Dougherty S, Wittliff JL, Klinge CM, Clem BF. Serine synthesis influences tamoxifen response in ER+ human breast carcinoma. Endocr Relat Cancer. 2021 Jan;28(1):27-37. doi: 10.1530/ERC-19-0510. PMID: 33112838; PMCID: PMC7780089.

    

2. O'Toole TE, Li X, Riggs DW, Hoetker DJ, Baba SP, Bhatnagar A. Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk. Int J Mol Sci. 2021 Jan 30;22(3):1383. doi: 10.3390/ijms22031383. PMID: 33573153; PMCID: PMC7866516.

    

3. Bhattacharyya A, Seth A, Srivast N, Imeokparia M, Rai S. Coronavirus (COVID-19): A Systematic Review and Meta-analysis to Evaluate the Significance of Demographics and Comorbidities. Res Sq [Preprint]. 2021 Jan 18:rs.3.rs-144684. doi: 10.21203/rs.3.rs-144684/v1. PMID: 33469575; PMCID: PMC7814834.

1. Hines-Martin, V.P. (2020). Community displacement, environmental change and the impact on mental well-being. Archives of Psychiatric Nursing, ISSN 0883-9417. https://doi.org/10.1016/j.apnu.2020.10.012.

    

2. O'Toole TE, Amraotkar AA, DeFilippis AP, Rai SN, Keith RJ, Baba SP, Lorkiewicz P, Crandell CE, Pariser GL, Wingard CJ, Pope Iii CA, Bhatnagar A. Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trial. BMJ Open. 2020 Dec 28;10(12):e039118. doi: 10.1136/bmjopen-2020-039118. PMID: 33372072; PMCID: PMC7772308.

    

3.  Dekhil O, Shalaby A, Soliman A, Mahmoud A, Kong M, Barnes G, Elmaghraby A, El-Baz A. (2021) Identifying brain areas correlated with ADOS raw scores by studying altered dynamic functional connectivity patterns. Med Image Anal. 2021 Feb;68:101899. doi: 10.1016/j.media.2020.101899. Epub 2020 Nov 12.PMID: 33260109

    

4. Chu T, Shields LBE, Zeng W, Zhang YP, Wang Y, Barnes GN, Shields CB, Cai J. (2021) Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes. Neural Regen Res. 2021 Jul;16(7):1359-1368. doi: 10.4103/1673-5374.300975.

1. Xie W, Kathuria H, Galiatsatos P, Blaha MJ, Hamburg NM, Robertson RM, Bhatnagar A, Benjamin EJ, Stokes AC. Association of Electronic Cigarette Use With Incident Respiratory Conditions Among US Adults From 2013 to 2018. JAMA Netw Open. 2020 Nov 2;3(11):e2020816. doi: 10.1001/jamanetworkopen.2020.20816. PMID: 33180127; PMCID: PMC7662143.

    

2. Xie C, Sun K, You Y, Ming Y, Yu X, Yu L, Huang J, Yan M. Correction to: Feasibility and efficacy of lung ultrasound to investigate pulmonary complications in patients who developed postoperative Hypoxaemia-a prospective study. BMC Anesthesiol. 2020 Nov 9;20(1):281. doi: 10.1186/s12871-020-01196-3. Erratum for: BMC Anesthesiol. 2020 Sep 1;20(1):220. PMID: 33167910; PMCID: PMC7650153.

    

3. Bowland, S. & Hines-Martin, V. (2020). Strengthening health in mixed-age housing communities. Journal of Health and Human Services Administration, 43(2), 218-234.

    

4. Song K, Xu Q, Koenig HM, Kong M, Slaughter MS, Huang Y, Clifford SP, Huang J. Validation of a Novel NeurOs Cerebral Oximetry Monitor Against the INVOS Monitor During Cardiac Surgery. J Cardiothorac Vasc Anesth. 2020 Oct 27:S1053-0770(20)31157-5. doi: 10.1053/j.jvca.2020.10.043. Epub ahead of print. PMID: 33218956.

    

5. Brier ME, Gooding JR, Harrington JM, Burgess JP, McRitchie SL, Zhang X, Rovin BH, Klein JB, Himmelfarb J, Sumner SJ, Merchant ML. Serum trace metal association with response to erythropoiesis stimulating agents in incident and prevalent hemodialysis patients. Sci Rep. 2020 Nov 19;10(1):20202. doi: 10.1038/s41598-020-77311-8. PMID: 33214633; PMCID: PMC7677396.

    

6. O'Toole TE, Li X, Riggs DW, Hoetker DJ, Yeager R, Lorkiewicz P, Baba SP, Cooper NGF, Bhatnagar A. Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants. Inhal Toxicol. 2020 Nov 12:1-9. doi: 10.1080/08958378.2020.1845257. Epub ahead of print. PMID: 33179563.

    

7. Das S, Rai SN. Statistical Approach for Biologically Relevant Gene Selection from High-Throughput Gene Expression Data. Entropy (Basel). 2020 Oct 25;22(11):E1205. doi: 10.3390/e22111205. PMID: 33286973.

    

8. Zierold KM, Sears CG, Hagemeyer AN, Brock GN, Polivka BJ, Zhang CH, Sears L. Protocol for measuring indoor exposure to coal fly ash and heavy metals, and neurobehavioural symptoms in children aged 6 to 14 years old. BMJ Open. 2020 Nov 23;10(11):e038960. doi: 10.1136/bmjopen-2020-038960. PMID: 33234632; PMCID: PMC7684807.

    

9. Leggett CS, Doll MA, States JC, Hein DW. Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes. Arch Toxicol. 2020 Nov 2. doi: 10.1007/s00204-020-02901-4. Epub ahead of print. PMID: 33136180.
10. Mo Y, Zhang Y, Wan R, Jiang M, Xu Y, Zhang Q. miR-21 mediates nickel nanoparticle-induced pulmonary injury and fibrosis. Nanotoxicology. 2020 Nov;14(9):1175-1197. doi: 10.1080/17435390.2020.1808727. Epub 2020 Sep 14. PMID: 32924694.

1. Mazzocco JC, Jagadapillai R, Gozal E, Kong M, Xu Q, Barnes GN, Freedman JH. Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet. Toxicol Rep. 2020 Aug 23;7:1164-1169. doi: 10.1016/j.toxrep.2020.08.005. PMID: 32983904; PMCID: PMC7494587.

    

2. Miller I, Scheffer IE, Gunning B, Sanchez-Carpintero R, Gil-Nagel A, Perry MS, Saneto RP, Checketts D, Dunayevich E, Knappertz V for GWPCARE2 Study Group (including G.N. Barnes). Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial. JAMA Neurol. 2020 May 1;77(5):613-621. doi: 10.1001/jamaneurol.2020.0073.

    

3. F. El-Gamal, M. Elmogy, A. Mohammed Ghazal, J. Yousaf, X. Qiu, H. Soliman, A. Atwan, H. Frieboes, G. Barnes, and A. El-Baz. (2020) Personalized Computer-Aided Diagnosis for Mild Cognitive Impairment in Alzheimer’s Disease Based on sMRI and11C PiB-PET Analysis, IEEE Access, Volume 8, DOI: 10.1109/ACCESS.2020.3038723.

    

4. Y. Elnakieb, M. Ali, A. Soliman, A. Mahmoud, A. Shalaby, N. Alghamdi, M. Ghazal, A. Khalil, A. Switala, R. Keynton, G. Barnes, and A. El-Baz. (2020) Computer Aided Autism Diagnosis Using Diffusion Tensor Imaging. IEEE ACCESS, Volume 8, Digital Object Identifier 10.1109/ACCESS.2020.3032066

    

5. Tian Z, Chu T, Shields LBE, Zhu Q, Zhang YP, Kong M, Barnes GN, Wang Y, Shields CB, Cai J. Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects. Mol Neurobiol. 2020 Oct;57(10):4069-4081. doi: 10.1007/s12035-020-02003-3. Epub 2020 Jul 13. PMID: 32661728.

    

6. Zhang Y, Cao H, Qiu X, Xu D, Chen Y, Barnes GN, Tu Y, Gyabaah AT, Gharbal AHAA, Peng C, Cai J, Cai X. Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice. Front Cell Neurosci. 2020 Jul 9;14:202. doi: 10.3389/fncel.2020.00202. PMID: 32733207; PMCID: PMC7363980.

    

7. Baba S, Smith T, Hellmann J, Bhatnagar A, Carter K, Vanhoover A, Caruso J. Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise. Nutrients. 2020 Aug 11;12(8):2400. doi: 10.3390/nu12082400. PMID: 32796546; PMCID: PMC7468946.

    

8. Galbraith NJ, Gardner SA, Walker SP, Trainor P, Carter JV, Bishop C, Sarojini H, O'Brien SJ, Bhatnagar A, Polk HC Jr, Galandiuk S. The role and function of IκKα/β in monocyte impairment. Sci Rep. 2020 Jul 22;10(1):12222. doi: 10.1038/s41598-020-68018-x. PMID: 32699255; PMCID: PMC7376008.

    

9. Irfan AB, Arab C, DeFilippis AP, Lorkiewicz P, Keith RJ, Xie Z, Bhatnagar A, Carll AP. Smoking Accelerates Atrioventricular Conduction in Humans Concordant with Increased Dopamine Release. Cardiovasc Toxicol. 2020 Oct 12. doi: 10.1007/s12012-020-09610-5. Epub ahead of print. PMID: 33043409.

    

10. Rai SN, Qian C, Pan J, Seth A, Srivastava DK, Bhatnagar A. Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients. BMC Med Res Methodol. 2020 Aug 31;20(1):220. doi: 10.1186/s12874-020-01101-z. PMID: 32867708; PMCID: PMC745675

     

11. Cave MC. Environmental Pollution and the Developmental Origins of Childhood Liver Disease. Hepatology. 2020 Nov;72(5):1518-1521. doi: 10.1002/hep.31549. PMID: 32910501.

     

12. Lin Q, Huang Z, Cai G, Fan X, Yan X, Liu Z, Zhao Z, Li J, Li J, Shi H, Kong M, Zheng MH, Conklin DJ, Epstein PN, Kupper AW, Mohammadi M, Cai L, Li X, Li Y, Tan Y. Activating AMP-activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection from Nonalcoholic Fatty Liver Disease in Mice. Hepatology. 2020 Sep 23. doi: 10.1002/hep.31568. Epub ahead of print. PMID: 32965675.

     

13. Mohamed TMA, Conklin DJ. Emerging technology and platforms for cardiotoxicity testing. Toxicol Appl Pharmacol. 2020 Dec 1;408:115262. doi: 10.1016/j.taap.2020.115262. Epub 2020 Oct 2. PMID: 33017593.

     

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