About Us
The Center for Cardiometabolic Science leads the way in the dissemination of new knowledge and supports discovery and training by developing technologically advanced approaches.
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Disseminating New Knowledge
This Center has the single greatest concentration of cardiovascular investigators both on UofL’s Health Sciences Center Campus and in the region. In addition to supporting the publication of cutting-edge cardiovascular science, faculty and trainees represent the Center at international conferences such as:
- American Heart Association (AHA) Scientific Sessions
- AHA Basic Cardiovascular Sciences
- International Society for Heart Research
- Society for Leukocyte Biology
- Tobacco Regulatory Science
- Society of Toxicology
- Bioactive Lipids Conference
- Physiology Summit (American Physiological Society)
Influencing the National Direction of Cardiovascular Research
Center faculty demonstrate national and international leadership by their participation in the most prestigious conferences, appointments to editorial boards of the best journals in the field, and positions on dozens of national grant review panels for the NIH, American Heart Association, Veterans Administration, and Department of Defense. Center members are also regularly featured as guest speakers at other universities and external advisory panels for other Centers. In addition, faculty are featured as subject matter experts by local media outlets.
Developing Technologically Advanced Approaches
Several of the Center’s faculty have contributed to advancements in health and disease phenotyping. The Center’s Physiology Core Director, Dr. Yibing Nong, has implemented several cutting-edge approaches to assess pump function and electrical activity in the heart. Dr. Jason Hellmann has overseen the Center’s metabolic and behavioral phenotyping systems, including a Promethion Core System, which measures whole body metabolism using indirect calorimetry and stable isotope gas analysis as well as voluntary exercise activity, feeding, and movement. He also organized the expansion of the Center’s exercise facility, which doubled the space and instrumentation to measure physical activity. On the microscopic end of the spectrum, Dr. Joseph Moore has established an imaging workflow to visualize the protein structures supporting the organization of the heart.
Instigating Translational Investigations
In addition to their own laboratory’s pursuits, our investigators have partnered with clinicians to measure a customized panel of metabolites, which may be useful in combatting heart disease. Other investigators are collaborating with UofL’s Chief of Cardiology to understand how metabolism regulates blood flow in patients’ hearts. In other human studies, one of our investigators has partnered with other members of the Envirome Institute to start an innovative human clinical trial using dietary supplements to treat patients with vascular disease.
The Center's History
Dr. Aruni Bhatnagar established the Diabetes and Obesity Center in 2008. Involved since the inception of that Center, Dr. Steven Jones assumed the directorship in 2019. To more accurately reflect the Center's scientific mission, we changed the name to the Center for Cardiometabolic Science. Our Center is the oldest and largest Center in the Envirome Institute. The Center is also the single greatest concentration of cardiovascular investigators at the University of Louisville School of Medicine.
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