Metabolism

Molecular and Metabolic Mechanisms of Cardiovascular Health and Disease 

The Gibb laboratory utilizes a wide-range of techniques from discovery-based screens, multi-omic approaches, in vitro mechanistic studies and in vivo models to uncover novel mechanisms of underlying cardiac health and disease.  

Mechanisms Contributing to Pregnancy-Induced Cardiac Remodeling 

Maternal health in the United States lags behind other high-income countries. The Collins laboratory led a multi-omics characterization of the maternal heart during and after pregnancy. Insights from their provocative work have led to potential biomarker candidates for beneficial and maladaptive changes in the maternal heart. 

Cardiovascular Benefits of Inhaled Biogenic Volatile Organic Compounds 

This project, directed by the Conklin laboratory, focuses on how plant-derived biogenic volatile organic chemicals (BVOCs) and their metabolites stimulate protective pathways in blood vessels. BVOCs show promise of improving cardiovascular function and dampening inflammation, thereby decreasing cardiovascular disease risk. Completion of this project will define the beneficial cardiovascular effects of inhaled BVOCs and could also lead to the development of biomarkers of exposure to greenness.  

Air Pollution, Circadian Rhythm Disruption and Cardiometabolic Disease  

The goal of this project, pursued by the Haberzettl laboratory, is to test the novel hypothesis that air pollution exposure disrupts vascular circadian rhythms and exacerbates cardiometabolic injury. Results of this project will be of significance in understanding and preventing the adverse health effects that originate from air pollution exposure. 

Cardiac Metabolism, Remodeling and Repair 

The Hill laboratory is focused on understanding the metabolic underpinnings of cardiovascular health and disease. Foundational findings from the Hill Lab have uncovered metabolic points of control in physiological and pathophysiological cardiac function and remodeling.